There's so many differences between them that its hard to pinpoint much without spoiling all the wonderful things that makes the live action sooo good.
That said, for general changes, I would say that the liveaction begins in a place where you think you know what is going to happen (It is set in the Dark Kingdom plotline, and you'd assume that you know the general idea of what's in the horizon) but that's right when the liveaction decides to go their own route, and throws in different curves and twists to keep you guessing.
Also, there's a bigger emphasis on the characters and their interactions with each other, as well as showing how all of the characters grow throughout the series. In my opinion, it's the best when it comes to showing off how intricate and wonderful the characters really are.